Buy Ksalol Xanax 1mg
What is Alprazolam?
Alprazolam is a triazolobenzodiazepine agent, belonging to a class of benzodiazepines. It has anxiolytic or anti-anxiety, sedative-hypnotic, or sleep inducing and anticonvulsant activities (for management of seizures or fits). Alprazolam belongs to a class of organic compounds known as 1, 2, 4-triazolo[4, 3-a][1, 4] benzodiazepines. These are aromatic compounds containing a 1, 4-benzodiazepine fused to and sharing a nitrogen atom with a 1, 2, 4-triazole ring. Alprazolam is solid and is practically insoluble in water and relatively neutral (neither acidic nor basic). They are class C drugs or schedule IV drugs, which have a potential for abuse or dependence and need a prescription for possession and consumption. Alprazolam is available in the UK, US, Canada, Australia and India online with a prescription. Anxiolytics are a group of drugs that control the symptoms of anxiety, produce a restful state of mind without interfering with normal mental or physical functions.
Alprazolam acts on the midbrain and binds to a specific site distinct from the inhibitory neurotransmitter gamma-amino-butyric acid (GABA) binding site on the benzodiazepine-A-GABA-Chlorine-Receptor ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS), these regions are responsible for the wakefulness and the thought and mental functions. The binding of the drug to its site-specific channel like a Lego block, causes neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability or other terms depressed the electrical activity of the nerves, thus the impulses travel at a lesser speed and also, lesser impulses get generated. Hence, during anxiety, the shooting of impulses through nerves which cause tremors, increase in heartbeat reduces.
These are frequently prescribed to manage panic and anxiety disorders. They have been misused for recreational purposes because it gives a sensation of euphoria or a state of “calmness” “happiness”. Alprazolam is also been used to treat insomnia, premenstrual syndrome, and depression. They are consumed as oral medications in the form of tablets, oral solutions, and suspensions. The tablets are available as Immediate-release tablets and Extended-release tablets (ER). The available dosage varies from 0.25mg-3mg. They cannot be bought without a doctor’s prescription and illegal possession of the drug has legal repercussions. Alprazolam is not an Over-the-counter drug. They are 20 times more potent than diazepam and have a shorter duration of action of 1-2 hours. Because of their increased potency, their actions have strong influences on the system. They are mainly excreted through the urine, but they are very dangerous to the liver.
How Alprazolam Acts?
Alprazolam acts on the midbrain, by acting as a tranquilizer with anti-anxiety, sedative-hypnotic, or sleep-inducing actions. They have a central depressant activity on the nervous system, the reason why it induces a state of “calmness” and relaxed state throughout the body. It acts mainly by increasing the effects of GABA (gamma-aminobutyric acid is an inhibitory neurotransmitter) by increasing GABA affinity at the GABA receptor. Therefore, GABA when bound to GABA-A receptor induces the calming or inhibitory effects of alprazolam on the nervous system.
Alprazolam is rapidly absorbed by the body. Reaches peak plasma or peak blood concentrations at 1-2 hours and its bioavailability or the amount of drug which is available for potential action is 80-100%. They are bound to the protein content in the blood, mainly albumin which constitutes 80% of all proteins in the blood.
Most of these proteins are produced by the liver. Alprazolam is metabolized or processed in the liver by the cytochrome P450 3A4 enzyme to active metabolites named 4-hydroxyalprazolam and alpha-hydroxyalprazolam. Even though it reaches its peak plasma concentrations in the blood within 1.5-2 hours, it is available in the blood for approximately 11.2 hours. Alprazolam is 20 times more potent than diazepam, meaning that less concentration of alprazolam is needed (compared to diazepam) to achieve the same effects as diazepam. the abuse and dependence of alprazolam are high in comparison to diazepam.
These have fewer actions on other body systems except for the liver. It causes hepatotoxicity by causing acute liver injury. Hence, patients with chronic alcoholism, fatty liver, liver cirrhosis, portal hypertension, and jaundice should be evaluated and the dosage should be adjusted prior. When alprazolam is taken with drugs that inhibit the liver enzyme CYP450, its blood concentrations remain high leading to long durations of CNS depressant actions.
Alprazolam crosses the mother-fetus (placental barrier) thus, it’s not indicated until it’s a LIFE-THREATENING scenario for the mother such that alprazolam has to be given. Maternal use shortly before delivery causes floppy infant syndrome and increases the risk of developing facial deformity such as clefts.
It is also secreted in human milk. Long term administration of alprazolam to nursing mothers has been known to cause their infants to become lethargic and lose weight considerably.
Since it causes central nervous system depression, its effect increases when the patient consumes alcohol, and it’s fatal. Very rarely, patients show allergic tendencies towards alprazolam, such as tightness in the chest, rashes, swelling of extremities, flushing; where the situation is known as anaphylaxis. In such situations, the physician should be sought immediately.
Alprazolam’s concomitant use with opioids, will results in profound respiratory depression or shallow and slow breathing, clammy and cold hands and feet, coma and death.
Alprazolam has a high tendency for abuse and dependence leading to death. Stopping abruptly or reducing dosage too quickly will cause withdrawal reaction, seizures, and is life-threatening. Since its metabolism occurs in the liver constant monitoring of the liver enzymes such as ALT and AST has to be done in chronic or long-term usage. Respiratory and cardiovascular system I.e., the heart and lung functioning must be monitored as it has a depressant action on both systems.
Owing to its CNS depressant effects, it is not advisable to drive a car/vehicle, operate machinery as it may turn out to be dangerous. Some drugs which are known to impact alprazolam include azole antifungals such as itraconazole, ketoconazole, proton-pump inhibitors such as cimetidine, certain anti-depressants like fluoxetine, fluvoxamine, and nefazodone, macrolide antibiotics such as erythromycin, clarithromycin), rifamycins (rifampin), St. John’s wort, seizure medications like carbamazepine, phenytoin), antihistamines and muscle relaxants such as succinylcholine, etc. Most of these increase the duration of action of the drug, as they inhibit the liver enzyme which metabolizes alprazolam.
What Are The Benefits Of Xanax/ Alprazolam?
Alprazolam predominantly has actions that aid in reducing the increased neuronal hyperactivity which leads to an anxious state or a panic state.
It helps in the management of anxiety disorders where patients present with (by definition) unrealistic or excessive anxiety and worry about two or more life circumstances, for a period of 6 months or longer, during which the person has been bothered more days than not by these concerns. They have motor tension such as trembling, twitching or feeling shaky, muscle tension, aches or soreness, restlessness, easy fatiguability, autonomic hyperactivity such as; (shortness of breath, palpitations or increased heart rate, sweating, or cold clammy hands, dry mouth, dizziness or light-headedness, nausea, diarrhea, or other abdominal distress, flushes or chills, frequent urination, trouble swallowing or ‘lump in the throat’); Vigilance and Scanning (feeling keyed up or on edge, exaggerated startle response, difficulty concentrating or ‘mind going blank’ because of anxiety, mental-black outs, trouble falling or staying asleep, easy irritability). These symptoms are most often not secondary to another psychiatric disorder.
Another definite indication is a panic disorder which is slightly different from anxiety disorders. characterized by recurrent unexpected panic attacks. By definition, there is a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes. These symptoms can be any of the following four; palpitations, pounding heart, or increased heart rate; sweating clammy hands; trembling or shaking; sensations of shortness of breath or smothering; feeling of choking (without food or anything in the mouth); chest pain or discomfort; nausea or abdominal distress; feeling dizzy, unsteady, lightheaded, or faint; derealization (feelings of unreality) or depersonalization (being detached from oneself); (10) fear of losing control; fear of dying; paresthesias (numbness or tingling sensations in extremities); chills or hot flushes (with no obvious change in surrounding temperature).
Alprazolam also combines the effect of central relaxation of muscles and induction of sleep, thus spreading a sense of “calm” throughout the body. It is also given before surgeries and dental treatments and for patients who have ADHD (attention deficit hyperactivity disorder). It rapidly reduces the heart rate because of which overdosage is fatal. Studies have proved that treatment of panic disorders for a period of 4-10 weeks has shown satisfactory results, while for anxiety disorders the duration for the treatment must be around 4 months.
How Should It Be Taken?
Alprazolam of all dosages is available only with a prescription. The cost of Xanax across UK street prices are estimated to be 1.50 euros for 1mg and 3-5euros for a 2mg Xanax tablet. They are also known as Alprazolam, Approx, Alpraz, Cassadan, Ralozam, Tafil, Trankimazin, etc. alprazolam Merck, Alprazolam Ranbaxy, Alprazolam Actavis, etc are a few drug names as well.
The dosage varies from 0.25mg to 3mg, they are available as 0.25mg, 0.5mg, 1mg, 2mg, 3mg and also as extended-release tablets. Oral solutions are available as 0.5mg/ml and as 1mg/10ml. consumption of alprazolam depends on the food. A high-fat meal taken about 2 hours before dosing increases the bioavailability by 25%. However, if the person has a stomach upset then it is advisable to take it with food. The extended-release tablets must not be chewed, crushed, or split but must be swallowed as a whole.
For anxiety, the dosage is about, 0.25 to 0.5mg, taken thrice a day. The dosage increase should occur at intervals of 3-4 days with increments of no more than 1mg per day. The maximum recommended dosage is 4mg. for geriatric people, the dosage is 0.25mg taken 2 to 3 times a day.
For panic disorders, when extended-release tablets are taken, alprazolam 1mg or 0.5mg is taken once a day with a maintenance dosage of 3-6mg orally er day. While the maximum recommended dosage is 10mg/day. When plain tablets or oral solutions are taken, alprazolam 0.5mg is taken thrice a day with a maximum recommended dosage of 10mg/day.
If the person has a liver disease or hepatic impairment, the oral dosage of plain tablets/ oral solutions is 0.25mg taken 2-3 times daily and when extended-release tablets are taken, it is 0.5mg orally, once daily.
Due to increased withdrawal symptoms, avoid abrupt stoppage of the drug. In all patients regardless of age, the dosage should undergo slow reduction when the treatment is being discontinued. The suggested method of daily dose reduction should not be more than 0.5mg every once in three days. In persons taking alprazolam for long durations should first switch to longer-acting benzodiazepines such as clonazepam or diazepam and titer it down gradually.
If you have skipped a dose, do not take it if the next dose is a few hours away. Strictly avoid double dosing to reduce marked CNS depressant effects.
Xanax tablets are available as follows:
0.25mg tablets are white in color, oval in shape, scored with “XANAX 0.25” imprinted on them. They are available in bottles of 100, Reverse Numbered Unit dose (100), Bottles of 500, and Bottles of 1000. 0.5mg tablets are peach in color, oval in shape, scored, and “XANAX 0.5” imprinted on them. They are available in bottles of 100, Reverse Numbered Unit dose (100), Bottles of 500, and Bottles of 1000.
1mg XANAX tablets are available in blue color, oval in shape with “XANAX 1.0” imprinted on them. Bottles of 100, 500, and 100 are only available. 2mg XANAX tablets are available in white color, oblong in shape, multi-scored with “XANAX” on one side, and “2” on the reverse side imprinted. Bottles of 500 and 100 are available. They must be stored at a controlled room temperature of 20-25 deg Celsius ( 68-77 deg Fahrenheit).
If you experience any side effects with Alprazolam, you should visit the physician immediately.
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